Food and Drug Administration (FDA), Dexedrine is a federally controlled substance (“Schedule II Stimulant”) because it can be abused or lead to dependence. if taking buspar, gabapentin, an atypical antipsychotic, or a benzodiazepine, dose has been stable for 4 weeks - has negative urine drug and pregnancy tests - is practicing reliable birth control method - has blood pressure readings at screening visit that are less than 140 mm Hg systolic and 90 mm Hg diastolic, - weight is greater than 100 lbs at screen Exclusion criteria: - requires psychotropic medications other than an Serotonin Reuptake Inhibitor (SRI), a benzodiazepine, buspirone, an atypical antipsychotic, and/or gabapentin - is taking clomipramine - is taking fluvoxamine - is taking medication that inhibits hepatic enzyme CYP1A2 - is taking a monoamine oxidase inhibitor - has co-morbid tics or Tourette's disorder - has hoarding as the primary or only OCD symptom - has a history of panic disorder - has a history of glaucoma - has a history of seizures - has a history of schizophrenia or psychotic disorder, or schizotypal personality disorder - has depression with current suicide risk - has mental retardation, pervasive developmental disorder, or cognitive disorder - has a factitious disorder - has current or past cyclothymic disorder or bipolar disorder - has a dissociative disorder - has personality disorder sufficient to interfere with study participation - has organic mental disorder or dementia - has current or past substance abuse / dependence (excluding nicotine) - has current or past anorexia or bulimia - has serious or unstable medical disorder, including hypertension or cardiac disease - has history of myocardial infarction or cardiac arrhythmia - has history of or has current diagnosis of hypertension - is pregnant or breast-feeding - is receiving psychotherapy for OCD - is intending to receive psychotherapy for OCD during the study - has had a previous trial of d-amphetamine of at least 30 days duration - is unable to speak, read, or understand English - is not likely to follow study procedures - is not suitable for study in the investigator's opinionĬontact information is only displayed when the study is recruiting subjects.Dexedrine (generic name: dextroamphetamine sulfate) is a long- or short-acting capsule, taken orally, that is primarily used to treat attention deficit hyperactivity disorder (ADHD or ADD) in children ages 3-12, adolescents, and adults. Inclusion Criteria: - outpatient age 18 through 55 inclusive - meets DSM-IV criteria for obsessive-compulsive disorder (OCD) with Yale-Brown Obsessive-Compulsive Scale (YBOCS) score greater than or equal to 20 - provides written informed consent - has taken for at least 12 weeks at least the dose shown of a selective serotonin reuptake inhibitor (SSRI) or venlafaxine 225 mg/d or duloxetine 60 mg/d. Duration: 5 weeks.Ĭaffeine dosage form: capsules identical to those in dextro-amphetamine arm, but containing 200 mg caffeine in Bottle A and 100 mg caffeine in Bottle B. ![]() Dosage: One capsule from Bottle A and one capsule from bottle B each morning. ![]() Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) Scoreĭextro-amphetamine dosage form: 15 mg capsules, in Bottles A and B. Number of Subjects With Clinical Global Impressions Scale - Improvement (CGI-I) Score of 1 or 2Īt end of week 5, except 1 d-amphetamine subject rated at end of week 2 The research will be performed only at Stanford University. This research study will enroll 24 people who are taking medication for their OCD but are not receiving sufficient benefit. A positive finding in this study may stimulate research aimed at improving OCD treatment and understanding of the neurochemistry involved. ![]() Koran believes it may be helpful in treating OCD. Because of the effects that d-amphetamine has on the brain, Dr. Food and Drug Administration to treat Attention Deficit Hyperactivity Disorder (ADHD) in children and adolescents. The study will investigate whether dextro-amphetamine (d-amphetamine) is safe and effective compared to caffeine as an active placebo when used to augment treatment for Obsessive-Compulsive Disorder (OCD), and whether tolerance (loss of therapeutic effect) to the medication will develop over a period of several weeks D-amphetamine is approved by the U.S.
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